Agr2^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Agr2^tm1.1Lex
• Name: anterior gradient 2; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5494472
• Gene: Agr2 Location: Chr12:36042924-36054080 bp, + strand Genetic Position: Chr12, 16.18 cM
• Alliance: Agr2^tm1.1Lex page

Mucosal hyperplasia in glandular stomach of Agr2^tm1.1Lex/Agr2^tm1.1Lex mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195573
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exons 2 through 5. QRT-PCR confirmed the absence of transcript expression in the stomach. (J:195573)

Schematic of the Agr2^tm1.1Lex allele

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agr2 Mutation: 34 strains or lines available

References

• Original: J:195573 Gupta A, et al., Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem. 2013 Feb 8;288(6):4321-33
• All: 1 reference(s)