Klb^tm1.1Akha
Targeted Allele Detail

Summary

• Symbol: Klb^tm1.1Akha
• Name: klotho beta; targeted mutation 1.1, Alexei Kharitonenkov
• MGI ID: MGI:5494481
• Gene: Klb Location: Chr5:65505657-65541350 bp, + strand Genetic Position: Chr5, 33.64 cM
• Alliance: Klb^tm1.1Akha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Flp-mediated recombination removed exons 1 through 4. Western blot analysis confirmed the absence of protein in the liver and white adipose tissue. (J:195570)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klb Mutation: 58 strains or lines available

References

• Original: J:195570 Adams AC, et al., FGF21 requires betaklotho to act in vivo. PLoS One. 2012;7(11):e49977
• All: 1 reference(s)