Fto^tm1.1Rdc
Targeted Allele Detail

Summary

• Symbol: Fto^tm1.1Rdc
• Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.1, Roger Cox
• MGI ID: MGI:5494489
• Synonyms: Fto^Flox
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^tm1.1Rdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194922
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:194922)

Schematic of the generation of Fto^tm1.1Rdc and Fto^tm1.2Rdc alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 75 strains or lines available

References

• Original: J:194922 McMurray F, et al., Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet. 2013 Jan;9(1):e1003166
• All: 1 reference(s)