Otud7b^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Otud7b^tm1Dgen
• Name: OTU domain containing 7B; targeted mutation 1, Deltagen
• MGI ID: MGI:5494636
• Gene: Otud7b Location: Chr3:96011839-96068446 bp, + strand Genetic Position: Chr3, 41.65 cM
• Alliance: Otud7b^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194553
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 38 bp in exon 6 were replaced with a lacZ-neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts and B cells. (J:194553)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otud7b Mutation: 45 strains or lines available

References

• Original: J:194553 Hu H, et al., OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3. Nature. 2013 Feb 21;494(7437):371-4
• All: 2 reference(s)