Pak2^tm1.1Cher
Targeted Allele Detail

Summary

• Symbol: Pak2^tm1.1Cher
• Name: p21 (RAC1) activated kinase 2; targeted mutation 1, Jonathan Chernoff
• MGI ID: MGI:5494659
• Synonyms: Pak2^flox, Pak2^tm1Daw
• Gene: Pak2 Location: Chr16:31835108-31898160 bp, - strand Genetic Position: Chr16, 22.4 cM
• Alliance: Pak2^tm1.1Cher page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195865
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by a 5' loxP site and a 3' loxP site. An frt-flanked neomycin selection cassette that was inserted 3' to exon 2 was removed via FLP=mediated recombination. (J:221555, J:235838)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pak2 Mutation: 66 strains or lines available

References

• Original: J:195865 Dorrance AM, et al., The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 2013 Mar 28;121(13):2474-82
• All: 18 reference(s)