Ston2^tm1Vha
Targeted Allele Detail

Summary

• Symbol: Ston2^tm1Vha
• Name: stonin 2; targeted mutation 1, Volker Haucke
• MGI ID: MGI:5494671
• Gene: Ston2 Location: Chr12:91599686-91753237 bp, - strand Genetic Position: Chr12, 45.02 cM
• Alliance: Ston2^tm1Vha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194336
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A neomycin resistance cassette replaced 1.3 kb of the coding sequence in exon 5, which comprises 70% of the coding sequence. Western blot analysis confirmed the absence of protein expression in the brain. (J:194336)

Generation of the Ston2^tm1Vha allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ston2 Mutation: 59 strains or lines available

Notes

ES cell = ES14.

References

• Original: J:194336 Kononenko NL, et al., Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E526-35
• All: 3 reference(s)