Syne4^tm1Kare
Targeted Allele Detail

Summary

• Symbol: Syne4^tm1Kare
• Name: spectrin repeat containing, nuclear envelope family member 4; targeted mutation 1, Karen B Avraham
• MGI ID: MGI:5494678
• Gene: Syne4 Location: Chr7:30014268-30018471 bp, + strand Genetic Position: Chr7, 17.39 cM
• Alliance: Syne4^tm1Kare page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194486
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES, lacZ and floxed neomycin resistance cassette replaced exons 2 through 6. Western blot analysis confirmed the absence of protein expression in salivary gland cells. (J:194486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne4 Mutation: 22 strains or lines available

References

• Original: J:194486 Horn HF, et al., The LINC complex is essential for hearing. J Clin Invest. 2013 Feb;123(2):740-50
• All: 4 reference(s)