Celf6^tm1.2Jdd
Targeted Allele Detail

Summary

• Symbol: Celf6^tm1.2Jdd
• Name: CUGBP, Elav-like family member 6; targeted mutation 1.2, Joseph D Dougherty
• MGI ID: MGI:5494708
• Gene: Celf6 Location: Chr9:59485200-59514575 bp, + strand Genetic Position: Chr9, 32.02 cM
• Alliance: Celf6^tm1.2Jdd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted, with an adjacent FRT flanked neomycin resistance cassette, upstream and downstream of exon 4. Mice were subsequently mated to flp expressing mice and the offspring mated to cre expressing mice to delete, first, the selection cassette, and then exon 4. Quantitative RT-PCR from mouse brain confirmed decreased mRNA. Immunological studies confirmed the absence of protein product in the brain. (J:194266)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Celf6 Mutation: 25 strains or lines available

References

• Original: J:194266 Dougherty JD, et al., The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. J Neurosci. 2013 Feb 13;33(7):2732-53
• All: 5 reference(s)