Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Giuseppe Pizzorno
• MGI ID: MGI:5494989
• Synonyms: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp}, UPase1-TG
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195165
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CAG-Upp1,-GFP)Gp} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Upp1 (MGI:1097668)

• Mutation details: The construct targeted to this locus contained a CAG promoter driving expression of the mouse cDNA followed by an IRES and GFP gene. Cre-mediated recombination removed the floxed neomycin cassette inserted downstream of the CAG promoter. Western blot analysis confirmed over-expression of the mouse gene. (J:195165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:195165 Le TT, et al., Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation. J Lipid Res. 2013 Apr;54(4):1044-57
• All: 5 reference(s)