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Tg(Tshb-cre)4Sac
Transgene Detail
Summary
Symbol: Tg(Tshb-cre)4Sac
Name: transgene insertion 4, Sally A Camper
MGI ID: MGI:5495135
Synonyms: Tg(Tshb-cre), Tg(Tshb-cre)4Sac
Transgene: Tg(Tshb-cre)4Sac  Location: unknown  
Alliance: Tg(Tshb-cre)4Sac page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Tshb-cre)4Sac expression driven by 1 gene
 
Mutation detailsRecombineering methods generated a construct in which a cre recombinase cassette was inserted at the transcriptional start site of Tshb in a BAC. Microinjection of the construct generated 4 cre-expressing founders which were crossed to reporter mice for activity analyses. Three lines demonstrated moderate levels of activity in the pituitary gland, but the activity was not specific to thyrotrophs. The other founder line 4 showed higher activity with greater thyrotroph specificity and was selected for further analysis. (J:197591)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tshb (species not specified)
Summary of all recombinase alleles driven by Tshb.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:197591 Castinetti F, et al., PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol. 2011 Nov;25(11):1950-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory