Tg(Tshb-cre)4Sac
Transgene Detail

Summary

• Symbol: Tg(Tshb-cre)4Sac
• Name: transgene insertion 4, Sally A Camper
• MGI ID: MGI:5495135
• Synonyms: Tg(Tshb-cre), Tg(Tshb-cre)4Sac
• Transgene: Tg(Tshb-cre)4Sac Location: unknown
• Alliance: Tg(Tshb-cre)4Sac page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tshb-cre)4Sac expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tshb

• Mutation details: Recombineering methods generated a construct in which a cre recombinase cassette was inserted at the transcriptional start site of Tshb in a BAC. Microinjection of the construct generated 4 cre-expressing founders which were crossed to reporter mice for activity analyses. Three lines demonstrated moderate levels of activity in the pituitary gland, but the activity was not specific to thyrotrophs. The other founder line 4 showed higher activity with greater thyrotroph specificity and was selected for further analysis. (J:197591)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tshb (species not specified) Summary of all recombinase alleles driven by Tshb. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:197591 Castinetti F, et al., PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol. 2011 Nov;25(11):1950-60
• All: 4 reference(s)