Krt1^tm1Tmm
Targeted Allele Detail

Summary

• Symbol: Krt1^tm1Tmm
• Name: keratin 1; targeted mutation 1, Thomas M Magin
• MGI ID: MGI:5495252
• Gene: Krt1 Location: Chr15:101753861-101759221 bp, - strand Genetic Position: Chr15, 57.06 cM
• Alliance: Krt1^tm1Tmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197699
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: The Hprt-mini cassette replaced exon 1, intron 1 and 415 bp of the 5' UTR. Western blot analysis confirmed the absence of protein in the skin. (J:200244)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt1 Mutation: 68 strains or lines available

References

• Original: J:197699 Wallace L, et al., Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. J Cell Sci. 2012 Apr 1;125(Pt 7):1750-8
• All: 2 reference(s)