Wnt1^tm1.1Mze
Targeted Allele Detail

Summary

• Symbol: Wnt1^tm1.1Mze
• Name: wingless-type MMTV integration site family, member 1; targeted mutation 1.1, Mark Zervas
• MGI ID: MGI:5495278
• Synonyms: Wnt1^fl, Wnt1^flox
• Gene: Wnt1 Location: Chr15:98687738-98691711 bp, + strand Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
• Alliance: Wnt1^tm1.1Mze page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194842
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-pgk-gb2-Neo-FRT-loxP cassette was inserted in intron 1 and a loxP site was inserted in intron 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:194842)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt1 Mutation: 31 strains or lines available

References

• Original: J:194842 Yang J, et al., Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
• All: 1 reference(s)