Kif7^dda
Chemically induced Allele Detail

Summary

• Symbol: Kif7^dda
• Name: kinesin family member 7; disorganized diaphragm allele
• MGI ID: MGI:5495412
• Synonyms: dd, Kif7^dd
• Gene: Kif7 Location: Chr7:79347846-79365468 bp, - strand Genetic Position: Chr7, 45.09 cM, cytoband D2
• Alliance: Kif7^dda page

Multiple developmental defects associated with syndromic congenital diaphragmatic hernia in Kif7^dda/Kif7^dda embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: A/J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation ENU induced an A to T nonsense mutation at position 2002 creating a premature stop in exon 8. (J:197449)

N-ethyl-N nitrosourea induced an A to T transversion generating the Kif7^dda allele

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif7 Mutation: 40 strains or lines available

References

• Original: J:197449 Coles GL, et al., Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
• All: 2 reference(s)