Flrt2^tm1.1Kln
Targeted Allele Detail

Summary

• Symbol: Flrt2^tm1.1Kln
• Name: fibronectin leucine rich transmembrane protein 2; targeted mutation 1.1, Rudiger Klein
• MGI ID: MGI:5495469
• Gene: Flrt2 Location: Chr12:95659000-95751989 bp, + strand Genetic Position: Chr12, 46.44 cM
• Alliance: Flrt2^tm1.1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196042
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the open reading frame in exon 2. Cre-mediated recombination removed the neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:196042)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flrt2 Mutation: 45 strains or lines available

References

• Original: J:196042 Yamagishi S, et al., FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 2011 Jul 20;30(14):2920-33
• All: 4 reference(s)