Unc5d^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Unc5d^tm1Kln
• Name: unc-5 netrin receptor D; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:5495472
• Gene: Unc5d Location: Chr8:29136745-29709664 bp, - strand Genetic Position: Chr8, 16.47 cM
• Alliance: Unc5d^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196042
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An cassette containing an IRES, Mapt and lacZ fusion (Tau-LacZ), and floxed neo cassette replaced the open reading frame in exon 8. The insertion results in a missense mutation in the ectodomain. Western blot analysis confirmed the absence of protein expression in the brain. (J:196042)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc5d Mutation: 46 strains or lines available

References

• Original: J:196042 Yamagishi S, et al., FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 2011 Jul 20;30(14):2920-33
• All: 3 reference(s)