Ddc^tm1.1Nwlh
Targeted Allele Detail

Summary

• Symbol: Ddc^tm1.1Nwlh
• Name: dopa decarboxylase; targeted mutation 1.1, Wuh-Liang Hwu
• MGI ID: MGI:5495816
• Synonyms: Ddc^IVS6
• Gene: Ddc Location: Chr11:11764101-11848144 bp, - strand Genetic Position: Chr11, 7.09 cM, cytoband A1-A4
• Alliance: Ddc^tm1.1Nwlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197646
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Intron 6 was replaced with a modified intron 6 with a mutation (A to T) 4 nucleotides into the intron affecting the exon 6 splice acceptor site, and a floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. Western blot analysis confirmed the lack of expression in the substantia nigra. (J:197646)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddc Mutation: 127 strains or lines available

References

• Original: J:197646 Lee NC, et al., Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency. Neurobiol Dis. 2013 Apr;52:177-90
• All: 3 reference(s)