Palb2^tm1.1Dli
Targeted Allele Detail

Summary

• Symbol: Palb2^tm1.1Dli
• Name: partner and localizer of BRCA2; targeted mutation 1.1, David M Livingston
• MGI ID: MGI:5495825
• Synonyms: Palb2^fl
• Gene: Palb2 Location: Chr7:121706485-121732203 bp, - strand Genetic Position: Chr7, 65.42 cM
• Alliance: Palb2^tm1.1Dli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197442
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and a second loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:197442)

Generation of the Palb2^tm1.1Dli allele

Tumor Data

List all tumor models in MMHCdb carrying Palb2^tm1.1Dli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Palb2 Mutation: 50 strains or lines available

References

• Original: J:197442 Bowman-Colin C, et al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7
• All: 5 reference(s)