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Mycntm1.1Mlit
Targeted Allele Detail
Summary
Symbol: Mycntm1.1Mlit
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1.1, Jian Fei
MGI ID: MGI:5495991
Synonyms: NmycTRE
Gene: Mycn  Location: Chr12:12986094-12991837 bp, - strand  Genetic Position: Chr12, 6.14 cM, cytoband A3-B
Alliance: Mycntm1.1Mlit page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196015
Parent Cell Line:  PRX-129S6 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe targeting construct inserted tetracycline response element (TRE or tetO) and a loxP site into intron 1 and fused EGFP, FRT-flanked neomycin resistance cassette and an additional loxP site to the ATG translation initiation site in exon 2. Cre-mediated recombination removed EGFP and FRT-flanked neomycin resistance cassette. (J:196015)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mycn Mutation:  25 strains or lines available
References
Original:  J:196015 Sun R, et al., Inducible and reversible regulation of endogenous gene in mouse. Nucleic Acids Res. 2012 Nov;40(21):e166
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory