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Pstpip1tm1.1Dtg
Targeted Allele Detail
Summary
Symbol: Pstpip1tm1.1Dtg
Name: proline-serine-threonine phosphatase-interacting protein 1; targeted mutation 1.1, Douglas T Golenbock
MGI ID: MGI:5496137
Synonyms: Pstpip1 del
Gene: Pstpip1  Location: Chr9:55997246-56036172 bp, + strand  Genetic Position: Chr9, 30.13 cM, cytoband C
Alliance: Pstpip1tm1.1Dtg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196002
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exons 4 through 11. Western blot analysis confirmed the absence of protein expression in the thymus, spleen and bone marrow. (J:196002)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pstpip1 Mutation:  14 strains or lines available
References
Original:  J:196002 Wang D, et al., Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15;288(7):4594-601
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory