Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Douglas T Golenbock |
MGI ID: |
MGI:5496225 |
Synonyms: |
Rosa-26-PSTPIP1 A230TSTOP del |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:196002
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PSTPIP1 (9051) |
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Mutation details: The targeting construct inserted into the locus contained a CAG promoter that drives ubiquitous expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of threonine for alanine at position 230 (A230T) preceded by a floxed STOP cassette and followed by an IRES and the truncated human CD2 tag. Cre-mediated recombination removed the floxed STOP cassette.
(J:196002)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
993 strains or lines available
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Original: |
J:196002 Wang D, et al., Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15;288(7):4594-601 |
All: |
1 reference(s) |
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