Gt(ROSA)26Sor^{tm1(CAG-PSTPIP1)Dtg}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-PSTPIP1)Dtg}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas T Golenbock
• MGI ID: MGI:5496233
• Synonyms: Rosa-26-PSTPIP1 WT^{STOP floxed}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-PSTPIP1)Dtg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196002
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-PSTPIP1)Dtg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSTPIP1 (9051)

  Pstpip1

  (MGI:1321396)

• Mutation details: The targeting construct inserted into the locus contained a CAG promoter that drives ubiquitous expression of the wild-type human cDNA preceded by a floxed STOP cassette and followed by an IRES and the truncated human CD2 tag. (J:196002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:196002 Wang D, et al., Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15;288(7):4594-601
• All: 1 reference(s)