Fcmr^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Fcmr^tm1Mak
• Name: Fc fragment of IgM receptor; targeted mutation 1, Tak Mak
• MGI ID: MGI:5496253
• Synonyms: Toso^-
• Gene: Fcmr Location: Chr1:130793514-130808528 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband E4
• Alliance: Fcmr^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194323
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin selection cassette replaced almost the entire coding region, extending from an intron in the 5' leader sequence pasted the last methionine codon. PCR and RT-PCR of various tissue extracts confirmed gene deletion. (J:194323)

Generation of the Fcmr^tm1Mak allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcmr Mutation: 28 strains or lines available

References

• Original: J:194323 Lang KS, et al., Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2593-8
• All: 7 reference(s)