Stk40^tm1Nju
Targeted Allele Detail

Summary

• Symbol: Stk40^tm1Nju
• Name: serine/threonine kinase 40; targeted mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:5496282
• Gene: Stk40 Location: Chr4:125997750-126034822 bp, + strand Genetic Position: Chr4, 59.89 cM
• Alliance: Stk40^tm1Nju page

Cyanosis and pulmonary atelectasis in Stk40^tm1Nju/Stk40^tm1Nju mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ and floxed neomycin resistance cassette replaced exons 2 and 3. Western blot analysis confirmed the absence of protein expression in lung tissue. (J:196001)

Generation of the Stk40^tm1Nju allele

Expression

In Mice Carrying this Mutation:	65 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk40 Mutation: 29 strains or lines available

References

• Original: J:196001 Yu H, et al., Deletion of STK40 protein in mice causes respiratory failure and death at birth. J Biol Chem. 2013 Feb 22;288(8):5342-52
• All: 5 reference(s)