Gt(ROSA)26Sor^tm2Iaai
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm2Iaai
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Iannis Aifantis
• MGI ID: MGI:5496402
• Synonyms: Rosa26^lsl-N1-IC
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm2Iaai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196407
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting constructed inserted between exon 1 and 2 contained a floxed splice acceptor neomycin resistance cassette and translation initiation site with 2 polyadenylation sequences followed by a truncated Notch1 cDNA encoding the intracellular domain. Cre-mediated recombination is required to achieve expression of the Notch2 intracellular domain. (J:196407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:196407 Lobry C, et al., Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med. 2013 Feb 11;210(2):301-19
• All: 1 reference(s)