Homer1^tm1Kino
Targeted Allele Detail

Summary

• Symbol: Homer1^tm1Kino
• Name: homer scaffolding protein 1; targeted mutation 1, Kaoru Inokuchi
• MGI ID: MGI:5496433
• Synonyms: Vesl-1L^-
• Gene: Homer1 Location: Chr13:93436143-93541637 bp, + strand Genetic Position: Chr13, 47.83 cM
• Alliance: Homer1^tm1Kino page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The portion coding the C-terminal 11 amino acids was replaced by a cDNA encoding the long form-specific C-terminal amino acid (exons 7 through 11) followed by a polyadenylation sequence and a neomycin resistance cassette. Northern blot analysis confirmed transcript expression of the long isoform and not the short isoform. (J:198336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Homer1 Mutation: 25 strains or lines available

References

• Original: J:198336 Inoue N, et al., Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation. Mol Brain. 2009;2:7
• All: 2 reference(s)