Zfp277^tm1Aiwa
Targeted Allele Detail

Summary

• Symbol: Zfp277^tm1Aiwa
• Name: zinc finger protein 277; targeted mutation 1, Atsushi Iwama
• MGI ID: MGI:5496522
• Gene: Zfp277 Location: Chr12:40365045-40495789 bp, - strand Genetic Position: Chr12, 18.06 cM
• Alliance: Zfp277^tm1Aiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198334
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette replaced exon 5. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:198334)

Generation of the Zfp277^tm1Aiwa allele

Tumor Data

List all tumor models in MMHCdb carrying Zfp277^tm1Aiwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp277 Mutation: 36 strains or lines available

References

• Original: J:198334 Negishi M, et al., A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One. 2010;5(8):e12373
• All: 2 reference(s)