Flg^tm1Amag
Targeted Allele Detail

Summary

• Symbol: Flg^tm1Amag
• Name: filaggrin; targeted mutation 1, Masayuki Amagai
• MGI ID: MGI:5496587
• Gene: Flg Location: Chr3:93180853-93200996 bp, + strand Genetic Position: Chr3, 40.16 cM
• Alliance: Flg^tm1Amag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198332
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 2 and 3. Westen blot analysis confirmed the absence of protein expression. (J:198332)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flg Mutation: 42 strains or lines available

References

• Original: J:198332 Kawasaki H, et al., Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol. 2012 Jun;129(6):1538-46.e6
• All: 7 reference(s)