Gt(ROSA)26Sor^{tm1(Bmi1)Aiwa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Bmi1)Aiwa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Atsushi Iwama
• MGI ID: MGI:5496634
• Synonyms: R26Stop^FLBmi1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Bmi1)Aiwa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198331
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: The targeting construct inserted a floxed neomycin resistance/STOP cassette, FLAG-tagged Bmi1 cDNA, IRES, EGFP and bovine polyadenylation sequence. (J:198331)

Generation of the Gt(ROSA)26Sor^tm1(Bmi1)Aiwa allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:198331 Nakamura S, et al., Bmi1 confers resistance to oxidative stress on hematopoietic stem cells. PLoS One. 2012;7(5):e36209
• All: 2 reference(s)