Phf2^tm1.2Yima
Targeted Allele Detail

Summary

• Symbol: Phf2^tm1.2Yima
• Name: PHD finger protein 2; targeted mutation 1.2, Yuuki Imai
• MGI ID: MGI:5496657
• Synonyms: Phf2^fl
• Gene: Phf2 Location: Chr13:48955226-49024361 bp, - strand Genetic Position: Chr13, 24.96 cM, cytoband A3-A4
• Alliance: Phf2^tm1.2Yima page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198329
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The construct targeted upstream of exon 6 contains (5' to 3') a loxP site, lacZ gene, FRT site, neomycin resistance cassette, loxP site and FRT site. An additional FRT site was inserted downstream of exon 6. Cre-mediated recombination removed the lacZ gene and neomycin resistance cassette and left exon 6 floxed. (J:198329)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phf2 Mutation: 46 strains or lines available

References

• Original: J:198329 Okuno Y, et al., Epigenetic regulation of adipogenesis by PHF2 histone demethylase. Diabetes. 2013 May;62(5):1426-34
• All: 2 reference(s)