Tsc2^tm1.1Kcess
Targeted Allele Detail

Summary

• Symbol: Tsc2^tm1.1Kcess
• Name: TSC complex subunit 2; targeted mutation 1.1, Kevin C Ess
• MGI ID: MGI:5496783
• Synonyms: Tsc2^f36-37
• Gene: Tsc2 Location: Chr17:24814790-24851604 bp, - strand Genetic Position: Chr17, 12.41 cM
• Alliance: Tsc2^tm1.1Kcess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195049
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 36. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 37. Flp-mediated recombination removed the neomycin resistance cassette and left exons 36 and 37 floxed. (J:195049)

Generation of the Tsc2^tm1.1Kcess allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tsc2 Mutation: 78 strains or lines available

References

• Original: J:195049 Fu C, et al., Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells. Genesis. 2013 Apr;51(4):284-92
• All: 4 reference(s)