Bcl11a^tm1Mbu
Targeted Allele Detail

Summary

• Symbol: Bcl11a^tm1Mbu
• Name: BCL11 transcription factor A; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:5496827
• Synonyms: Bcl11a^fl
• Gene: Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
• Alliance: Bcl11a^tm1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196405
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. The construct targeted to exon 4 downstream of the stop condon contains (5' to 3') 6 polyadenylation sequences, a loxP site, unspecified recombination site, EGFP with a signal sequence, 2 polyadenylation sequences, neomycin resistance cassette and unspecified recombination site. (J:196405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11a Mutation: 44 strains or lines available

References

• Original: J:196405 Esteghamat F, et al., Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice. Blood. 2013 Mar 28;121(13):2553-62
• All: 1 reference(s)