Pip5k1c^tm1Csab
Targeted Allele Detail

Summary

• Symbol: Pip5k1c^tm1Csab
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 1, Charles Abrams
• MGI ID: MGI:5496873
• Synonyms: PIP5KIgammaE17^-
• Gene: Pip5k1c Location: Chr10:81128797-81155807 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Pip5k1c^tm1Csab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196476
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP/FRT flanked Neo cassette was inserted on the 5' side of exon 17, and a single loxP site was inserted at the 3' side of exon 17. The target region is 721 bp and includes exon 17. The homology recombination in embryonic stem cells was confirmed by Southern blotting combined with sequence analysis. (J:196476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip5k1c Mutation: 41 strains or lines available

References

• Original: J:196476 Wang Y, et al., Platelets lacking PIP5KIgamma have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood. 2013 Apr 4;121(14):2743-52
• All: 1 reference(s)