Pip5k1c^tm2Csab
Targeted Allele Detail

Summary

• Symbol: Pip5k1c^tm2Csab
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 2, Charles Abrams
• MGI ID: MGI:5496877
• Synonyms: PIP5KIgamma^-
• Gene: Pip5k1c Location: Chr10:81128797-81155807 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Pip5k1c^tm2Csab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196476
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct used has lox recombination sites flanking the splice acceptor of a beta-geo fusion gene that was inserted into intron 1. In the unrecombined state, the presence of the beta-geo fusion gene disrupts expression of the gene. Upon recombination, splicing and expression of the endogenous gene can be restored. (J:196476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip5k1c Mutation: 41 strains or lines available

References

• Original: J:196476 Wang Y, et al., Platelets lacking PIP5KIgamma have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood. 2013 Apr 4;121(14):2743-52
• All: 1 reference(s)