Tg(Twnk)1Lrsn
Transgene Detail

Summary

• Symbol: Tg(Twnk)1Lrsn
• Name: transgene insertion 1, Nils-Goran Larsson
• MGI ID: MGI:5496879
• Synonyms: Tg(Peo1)1Lrsn, Twinkle BAC tg
• Transgene: Tg(Twnk)1Lrsn Location: unknown
• Alliance: Tg(Twnk)1Lrsn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Twnk)1Lrsn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Twnk (MGI:2137410)

• Mutation details: A BAC clone (RP23-34C7) containing the Peo1 (Twinkle) sequence was used to generate the transgenic construct. Recombineering methods introduced a synonynmous change in the coding sequence which created an XhoI restriction site in exon 1. The purified construct was microinjected into pronuclei of one-stage mouse embryos. Line information is not available.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194965 Milenkovic D, et al., TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum Mol Genet. 2013 May 15;22(10):1983-93
• All: 1 reference(s)