Slc18a2^tm1.1Bgir
Targeted Allele Detail

Summary

• Symbol: Slc18a2^tm1.1Bgir
• Name: solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1.1, Bruno Giros
• MGI ID: MGI:5496922
• Synonyms: VMAT2^lox
• Gene: Slc18a2 Location: Chr19:59249328-59284444 bp, + strand Genetic Position: Chr19, 54.64 cM
• Alliance: Slc18a2^tm1.1Bgir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the first coding exon. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of the first coding sequence. FLP-mediated recombination removed the neomycin resistance cassette and leave the first coding exon floxed. (J:197966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc18a2 Mutation: 29 strains or lines available

References

• Original: J:197966 Narboux-Neme N, et al., Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology. 2011 Nov;36(12):2538-50
• All: 13 reference(s)