Card11^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Card11^M2Btlr
• Name: caspase recruitment domain family, member 11; mutation 2, Bruce Beutler
• MGI ID: MGI:5497995
• Synonyms: May
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The causative mutation is a C to T transition at base pair 140876495 (v38) on Chromosome 5 in the GenBank genomic region NC_000071 encoding Card11. The mutation corresponds to residue 3367 in the mRNA sequence NM_175362 within exon 23 of 25 total exons. The mutation results in an arginine (R) to premature stop codon substitution at amino acid 1016. (J:198555) Additional incidental mutations were detected in sequencing for the causative mutation, Card11^M2Btlr, and may be present in stocks carrying this mutation.
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

Notes

Whole exome HiSeq sequencing of one of the resulting mice, an affected female, identified 26 mutations.

References

• Original: J:198555 Beutler B, Direct data submission for a Card11 allele. MGI Direct Data Submission. 2013
• All: 1 reference(s)