Ifnar1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ifnar1^m2Btlr
• Name: interferon (alpha and beta) receptor 1; mutation 2, Bruce Beutler
• MGI ID: MGI:5498008
• Synonyms: shook
• Gene: Ifnar1 Location: Chr16:91282126-91304329 bp, + strand Genetic Position: Chr16, 52.98 cM
• Alliance: Ifnar1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Sequencing of the causative mutated gene identified a C to T transition at base pair 91499537 (v38) on Chromosome 16 in the GenBank genomic region NC_000082 encoding Ifnar1. The mutation corresponds to residue 1054 in the mRNA sequence (NM_010508.2) within exon 7 of 11 total exons. The mutation results in a glutamine (Q) to premature stop codon (*) substitution at residue 309. (J:198556)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifnar1 Mutation: 60 strains or lines available

Notes

Whole exome HiSeq sequencing of the G1 grandsire identified 59 mutations.

References

• Original: J:198556 Beutler B, Direct data submission for an Ifnar1 allele. MGI Direct Data Submission. 2013
• All: 1 reference(s)