Gt(ROSA)26Sor^tm1Fan
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Fan
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Chen-Ming Fan
• MGI ID: MGI:5498471
• Synonyms: ROSA^AC
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Fan page

Skeletal defects in Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan Tg(T-cre)1Lwd/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Dominant negative, Inserted expressed sequence, Reporter) Mutation: Insertion Mutation details: A cassette containing a CMV/beta-actin promoter/enhancer, a loxP-Neo-3xpA-loxP stop signal, A-CREB, an IRES and a nuclear localized EGFP was inserted into the locus via homologous recombination. Acidic CREB (A-CREB) acts as a highly selective pan-dominant-negative reagent to the CREB gene family and consists of an acidic amphipathic extension fused to the N terminus of the CREB leucine zipper domain. (J:197427)

Generation of the Gt(ROSA)26Sor^tm1Fan allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 991 strains or lines available

References

• Original: J:197427 Lopez TP, et al., Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2019-27
• All: 2 reference(s)