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Gt(ROSA)26Sortm1Fan
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1Fan
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Chen-Ming Fan
MGI ID: MGI:5498471
Synonyms: ROSAAC
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1Fan page
Skeletal defects in Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan Tg(T-cre)1Lwd/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197427
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Dominant negative, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing a CMV/beta-actin promoter/enhancer, a loxP-Neo-3xpA-loxP stop signal, A-CREB, an IRES and a nuclear localized EGFP was inserted into the locus via homologous recombination. Acidic CREB (A-CREB) acts as a highly selective pan-dominant-negative reagent to the CREB gene family and consists of an acidic amphipathic extension fused to the N terminus of the CREB leucine zipper domain. (J:197427)
Generation of the Gt(ROSA)26Sortm1Fan allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:197427 Lopez TP, et al., Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2019-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory