b2b2110Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b2110Clo
• Name: Mutant line 2110; Bench to Bassinet Program (B2B/CVDC), mutation 2110 Cecilia Lo
• MGI ID: MGI:5498488
• Synonyms: Weasley
• Gene: b2b2110Clo Location: unknown
• Alliance: b2b2110Clo page

Mutant 2110-002-2 (E14.5) exhibits hypoplastic transverse arch with posterior positioning of the pulmonary artery, consistent with the finding of double outlet right ventricle by EFIC examination

Show the 11 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This ENU-induced mutation line was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See b2b2110.1Clo and b2b2110.2Clo (J:175213)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b2110Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Mutant Type 1: Cardiac phenotype (1 mutant): Double outlet right ventricle (DORV) with hypoplastic aortic arch
Mutant Type 2: Cardiac phenotype: Biventricular hypertrophy
Noncardiac phenotype: Anopthalmia/micropthalmia, craniofacial defects including agnathia, micrognathia and cleft palate

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
2704	Aortic arch hypoplasia
4163	Micrognathia
4876	Cleft palate
7505	Biventricular hypertrophy

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)