Tg(Col1a1-FGF2*,-Sapphire)305Mmh
Transgene Detail
|
Symbol: |
Tg(Col1a1-FGF2*,-Sapphire)305Mmh |
Name: |
transgene insertion 305, Marja M Hurley |
MGI ID: |
MGI:5498524 |
Synonyms: |
18-kDa(305)TgFGF2, Col3.6- LMW-IRES-GFPsaph |
Transgene: |
Tg(Col1a1-FGF2*,-Sapphire)305Mmh Location: unknown
|
Alliance: |
Tg(Col1a1-FGF2*,-Sapphire)305Mmh page
|
|
Trabecular and cortical bone abnormalities in homozygous Tg(Col1a1-FGF2*,-Sapphire)305Mmh and Tg(Col1a1-FGF2*,-Sapphire)308Mmh mice
Show the 3 phenotype image(s) involving this allele.
|
|
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Col1a1-FGF2*,-Sapphire)305Mmh expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FGF2 (2247) |
|
|
|
|
|
Mutation details: A transgene designed to contain the human low-molecular weight exported 18-kDa isoform of FGF2, an internal ribosome entry site (IRES), and a blue shifted variant of GFP known as Sapphire under the control of a 3.6 kb fragment of the Col1a1 5' regulatory region (Col3.6). The construct also harbors a neomycin selection cassette. Founder line 305 was established. Western blot analysis demonstrates high levels of expression of 18-kDa FGF2 in femurs and calvariae, low levels of expression in liver, and no expression in other tissues.
(J:147213)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:147213 Xiao L, et al., Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice. J Biol Chem. 2009 Jan 30;284(5):3170-82 |
All: |
4 reference(s) |
|