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Tg(Col1a1-FGF2*,-Sapphire)305Mmh
Transgene Detail
Summary
Symbol: Tg(Col1a1-FGF2*,-Sapphire)305Mmh
Name: transgene insertion 305, Marja M Hurley
MGI ID: MGI:5498524
Synonyms: 18-kDa(305)TgFGF2, Col3.6- LMW-IRES-GFPsaph
Transgene: Tg(Col1a1-FGF2*,-Sapphire)305Mmh  Location: unknown  
Alliance: Tg(Col1a1-FGF2*,-Sapphire)305Mmh page
Trabecular and cortical bone abnormalities in homozygous Tg(Col1a1-FGF2*,-Sapphire)305Mmh and Tg(Col1a1-FGF2*,-Sapphire)308Mmh mice

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Col1a1-FGF2*,-Sapphire)305Mmh expresses 1 gene
 
Mutation detailsA transgene designed to contain the human low-molecular weight exported 18-kDa isoform of FGF2, an internal ribosome entry site (IRES), and a blue shifted variant of GFP known as Sapphire under the control of a 3.6 kb fragment of the Col1a1 5' regulatory region (Col3.6). The construct also harbors a neomycin selection cassette. Founder line 305 was established. Western blot analysis demonstrates high levels of expression of 18-kDa FGF2 in femurs and calvariae, low levels of expression in liver, and no expression in other tissues. (J:147213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:147213 Xiao L, et al., Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice. J Biol Chem. 2009 Jan 30;284(5):3170-82
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory