Usp10^tm1Fuj
Targeted Allele Detail

Summary

• Symbol: Usp10^tm1Fuj
• Name: ubiquitin specific peptidase 10; targeted mutation 1, Masahiro Fujii
• MGI ID: MGI:5498660
• Synonyms: Usp10^delta
• Gene: Usp10 Location: Chr8:120637099-120684299 bp, + strand Genetic Position: Chr8, 68.61 cM, cytoband E1
• Alliance: Usp10^tm1Fuj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194412
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was deleted. RT-PCR confirmed a peptide product consistent with 30 N-terminal amino acids and 11 amino acids from an "out of frame" exon 4 translation. Western blot analysis confirmed the absence of native protein. This allele was generated from Usp10^tm2.1Fuj (J:194412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp10 Mutation: 58 strains or lines available

References

• Original: J:194412 Takahashi M, et al., Stress granules inhibit apoptosis by reducing reactive oxygen species production. Mol Cell Biol. 2013 Feb;33(4):815-29
• All: 2 reference(s)