Mad2l1^tm2Sorg
Targeted Allele Detail

Summary

• Symbol: Mad2l1^tm2Sorg
• Name: MAD2 mitotic arrest deficient-like 1; targeted mutation 2, Peter K Sorg
• MGI ID: MGI:5498674
• Synonyms: Mad2^f, Mad2l1^f
• Gene: Mad2l1 Location: Chr6:66512205-66518091 bp, + strand Genetic Position: Chr6, 30.56 cM
• Alliance: Mad2l1^tm2Sorg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194539
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were introduced flanking exons 2 to part of exon 5. (J:194539, J:256859)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mad2l1^tm2Sorg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mad2l1 Mutation: 14 strains or lines available

References

• Original: J:194539 Foijer F, et al., Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2928-33
• All: 4 reference(s)