Aurka^tm1.2Sbsn
Targeted Allele Detail

Summary

• Symbol: Aurka^tm1.2Sbsn
• Name: aurora kinase A; targeted mutation 1.2, Subrata Sen
• MGI ID: MGI:5498678
• Gene: Aurka Location: Chr2:172198110-172212455 bp, - strand Genetic Position: Chr2, 94.84 cM
• Alliance: Aurka^tm1.2Sbsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198479
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression. (J:198479)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aurka Mutation: 40 strains or lines available

References

• Original: J:198479 Sasai K, et al., Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality. Oncogene. 2008 Jul 3;27(29):4122-7
• All: 1 reference(s)