Il17ra^tm1.2Kurs
Targeted Allele Detail

Summary

• Symbol: Il17ra^tm1.2Kurs
• Name: interleukin 17 receptor A; targeted mutation 1.2, Florian C Kurschus
• MGI ID: MGI:5498882
• Synonyms: IL-17RA^del
• Gene: Il17ra Location: Chr6:120440143-120460692 bp, + strand Genetic Position: Chr6, 56.95 cM
• Alliance: Il17ra^tm1.2Kurs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196483
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomyocin resistance cassette with a 5' loxP site was inserted usptream of exon 4. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 4 through 7 and the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expresion in the spleen. (J:196483)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Il17ra^tm1.2Kurs/Il17ra^tm1.2Kurs	involves: 129S4/SvJae * BALB/cJ * C57BL/6 * SJL

Phenotypes:

Affected Systems	hm1
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hematopoietic system	√
increased CD4-positive, alpha-beta T cell number	√
increased T-helper 17 cell number	√
increased gamma-delta T cell number	√
immune system	√
increased CD4-positive, alpha-beta T cell number	√
increased T-helper 17 cell number	√
increased gamma-delta T cell number	√
abnormal interleukin secretion	√
increased interleukin-17 secretion	√
increased interleukin-6 secretion	√
skin inflammation	√
integument	√
skin inflammation	√
psoriasis	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17ra Mutation: 47 strains or lines available

References

• Original: J:196483 El Malki K, et al., An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol. 2013 Feb;133(2):441-51
• All: 4 reference(s)