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Oasl1tm1Yjk
Targeted Allele Detail
Summary
Symbol: Oasl1tm1Yjk
Name: 2'-5' oligoadenylate synthetase-like 1; targeted mutation 1, Young-Joon Kim
MGI ID: MGI:5498949
Synonyms: Oasl1tm1Lms
Gene: Oasl1  Location: Chr5:115061299-115075974 bp, + strand  Genetic Position: Chr5, 55.99 cM
Alliance: Oasl1tm1Yjk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194467
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 2 has been replaced by a neomycin resistance cassette. RNA and protein analysis confirmed the absence of gene product. (J:194467)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oasl1 Mutation:  33 strains or lines available
References
Original:  J:194467 Lee MS, et al., OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7. Nat Immunol. 2013 Apr;14(4):346-55
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory