Oasl1^tm1Yjk
Targeted Allele Detail

Summary

• Symbol: Oasl1^tm1Yjk
• Name: 2'-5' oligoadenylate synthetase-like 1; targeted mutation 1, Young-Joon Kim
• MGI ID: MGI:5498949
• Synonyms: Oasl1^tm1Lms
• Gene: Oasl1 Location: Chr5:115061299-115075974 bp, + strand Genetic Position: Chr5, 55.99 cM
• Alliance: Oasl1^tm1Yjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194467
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 has been replaced by a neomycin resistance cassette. RNA and protein analysis confirmed the absence of gene product. (J:194467)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oasl1 Mutation: 33 strains or lines available

References

• Original: J:194467 Lee MS, et al., OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7. Nat Immunol. 2013 Apr;14(4):346-55
• All: 4 reference(s)