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Pros1tm1.2Grl
Targeted Allele Detail
Summary
Symbol: Pros1tm1.2Grl
Name: protein S (alpha); targeted mutation 1.2, Greg Lemke
MGI ID: MGI:5499100
Gene: Pros1  Location: Chr16:62674670-62749709 bp, + strand  Genetic Position: Chr16, 36.43 cM
Alliance: Pros1tm1.2Grl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198769
Parent Cell Line:  2A (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 15. Cre-mediated recombination removed exons 11 through 15 and the neomycin resistance cassette. (J:198769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pros1 Mutation:  44 strains or lines available
References
Original:  J:198769 Burstyn-Cohen T, et al., Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009 Oct;119(10):2942-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory