Pros1^tm1.2Grl
Targeted Allele Detail

Summary

• Symbol: Pros1^tm1.2Grl
• Name: protein S (alpha); targeted mutation 1.2, Greg Lemke
• MGI ID: MGI:5499100
• Gene: Pros1 Location: Chr16:62674670-62749709 bp, + strand Genetic Position: Chr16, 36.43 cM
• Alliance: Pros1^tm1.2Grl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198769
• Parent Cell Line: 2A (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 15. Cre-mediated recombination removed exons 11 through 15 and the neomycin resistance cassette. (J:198769)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pros1 Mutation: 44 strains or lines available

References

• Original: J:198769 Burstyn-Cohen T, et al., Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009 Oct;119(10):2942-53
• All: 1 reference(s)