Erf^tm2Gmav
Targeted Allele Detail

Summary

• Symbol: Erf^tm2Gmav
• Name: Ets2 repressor factor; targeted mutation 2, George Mavrothalassitis
• MGI ID: MGI:5499177
• Synonyms: Erf^loxP
• Gene: Erf Location: Chr7:24941986-24950186 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Erf^tm2Gmav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198059
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of the second coding exon. An additional loxP site was inserted downstream of the STOP codon in the fourth coding exon. RT-PCR confirmed reduced transcript expression. This allele is hypomorphic. (J:198059)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erf Mutation: 31 strains or lines available

References

• Original: J:198059 Twigg SR, et al., Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet. 2013 Mar;45(3):308-13
• All: 3 reference(s)