Erf^tm2.1Gmav
Targeted Allele Detail

Summary

• Symbol: Erf^tm2.1Gmav
• Name: Ets2 repressor factor; targeted mutation 2.1, George Mavrothalassitis
• MGI ID: MGI:5499178
• Gene: Erf Location: Chr7:24941986-24950186 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Erf^tm2.1Gmav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198059
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of the second coding exon. An additional loxP site was inserted downstream of the STOP codon in the fourth coding exon. Cre-mediated recombination removed the coding sequence between the loxP sites. (J:198059)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erf Mutation: 31 strains or lines available

References

• Original: J:198059 Twigg SR, et al., Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet. 2013 Mar;45(3):308-13
• All: 1 reference(s)