Kdm6a^tm1.1Afst
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1.1Afst
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1.1, A Stewart
• MGI ID: MGI:5499290
• Synonyms: UTX^FDC
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1.1Afst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196401
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked STOP cassette with a 3' loxP site was inserted upstream of exon 3. A rox flanked hygromycin resistance (hygro) cassette with a 3' loxP site was inserted downstream of exon 3. Flp- and dre-mediated recombination removed the STOP and hygro cassettes. (J:196401)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 40 strains or lines available

References

• Original: J:196401 Thieme S, et al., The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood. 2013 Mar 28;121(13):2462-73
• All: 1 reference(s)