Wwox^tm2.1Ria
Targeted Allele Detail

Summary

• Symbol: Wwox^tm2.1Ria
• Name: WW domain-containing oxidoreductase; targeted mutation 2.1, Rami I Aqeila
• MGI ID: MGI:5499852
• Synonyms: Wwox^delta
• Gene: Wwox Location: Chr8:115166395-116079447 bp, + strand Genetic Position: Chr8, 60.99 cM, cytoband E1
• Alliance: Wwox^tm2.1Ria page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was floxed. An FRT-flanked neo cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in the liver. Immunohistochemistry confirmed the absence of protein expression in the bone tissue. (J:198845)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwox Mutation: 59 strains or lines available

References

• Original: J:198845 Abdeen SK, et al., Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype. J Cell Physiol. 2013 Jul;228(7):1377-82
• All: 1 reference(s)